MUELLER MATRIX MICROSCOPY FOR QUANTITATIVE ASSESSMENT OF MICROAND MACRO-STRUCTURE OF BIOLOGICAL SPECIMEN
Tsinghua University, China
Polarization techniques are powerful tools for probing the micro- and macro- structure and optical properties of complex anisotropic turbid media since the polarization states of the scattered photons are affected by the size, shape, orientation and alignment of the scattering particles as well as the absorption, refraction and optical activity of the interstitial substance of the media. Various polarization techniques have been used in different applications ranging from material characterization to clinical diagnosis. Mueller matrix represents a comprehensive characterization of polarization properties of the scattering sample. Parameters of all the existing polarization techniques can be expressed as functions of the Mueller matrix elements. In this paper, we report our recent efforts to develop a Mueller matrix microscope for imaging thin slices of clinical tissue samples and to identify new polarization parameters for quantitatively characterizing the structural features of pathological abnormalities for diagnosis applications.