MULTIPHOTON IMAGING OF CORNEA DEVELOPMENT AND PATHOLOGY
Chen Yuan Dong
National Taiwan University, Taiwan
Due to the high degree of corneal transparency, standard optical microscopy examination is of limited use in imaging superstructure in normal and pathological corneas. However, since the cornea is composed primarily of type I collagen, a combination nonlinear optical phenomena such as multiphotoninduced fluorescence and second harmonic generation (SHG) has been shown to be effective in visualizing three-dimensional superstructure and pathological changes in corneal specimens. In this presentation, I will show our results in investigating cornea development and pathology. I will also discuss future research directions and potential development in the clinical setting.